TOPIC / ISSUE

A topic is what the essay or research paper is about. It provides a focus for the writing. Of course, the major topic can be broken down into its components or smaller pieces (e.g., the major topic of nuclear waste disposal may be broken down into medical, economic, and environmental concerns). But the important thing to remember is that you should stick with just one major topic per essay or research paper in order to have a coherent piece of writing.

An issue is a concept upon which you can take a stand. While "nuclear waste" is a topic, "safe and economic disposal of nuclear waste" is an issue, or a "point of discussion, debate, or dispute" (American Heritage Dictionary).